Influence of 2-chlorodeoxyadenosine (cladribine) on human erythrocytes.

  title={Influence of 2-chlorodeoxyadenosine (cladribine) on human erythrocytes.},
  author={Agnieszka Marczak and Dorota Łubgan and Tadeusz Robak and Zofia J{\'o}źwiak},
  journal={The international journal of biochemistry & cell biology},
  volume={36 8},
2-Chlorodeoxyadenosine (2-CdA, cladribine) is one of the newest chemotherapy drugs which has been around and in use for a few years. Drug in tumour cells causes the inhibition of DNA synthesis and repair processes in replication cells, and the accumulation of DNA strand breaks in nonproliferating cells. The present study was undertaken to characterize the influence of cladribine on the fluidity of the lipid bilayer and protein conformation in human erythrocytes. The effect of cladribine on the… CONTINUE READING