Influence of 2-(4-aminophenyl)benzothiazoles on growth of human ovarian carcinoma cells in vitro and in vivo.

@article{Bradshaw1998InfluenceO2,
  title={Influence of 2-(4-aminophenyl)benzothiazoles on growth of human ovarian carcinoma cells in vitro and in vivo.},
  author={Tracey D Bradshaw and Dalong Shi and R. Jack Schultz and Kenneth D. Paull and Lloyd Kelland and Andy Wilson and Colin R Garner and Heinz Herbert Fiebig and Stephen Wrigley and Malcolm F. G. Stevens},
  journal={British Journal of Cancer},
  year={1998},
  volume={78},
  pages={421 - 429}
}
2-(4-Aminophenyl)benzothiazole molecules substituted in the 3 position of the phenyl ring with a halogen atom or methyl moiety comprise a group of compounds that potently inhibit specific human ovarian carcinoma cell lines. GI50 values fall within the nM range. Inhibition is highly selective -- whereas the GI50 value in IGROV1 cells consistently lies at < 10 nM, SK-OV-3 presents GI50 values > 10 microM. Biphasic dose-response relationships were observed in sensitive cell lines after 48-h drug… CONTINUE READING