Influence of 17-Hydroxyprogesterone, Progesterone and Sex Steroids on Mineralocorticoid Receptor Transactivation in Congenital Adrenal Hyperplasia

@article{Mooij2015InfluenceO1,
  title={Influence of 17-Hydroxyprogesterone, Progesterone and Sex Steroids on Mineralocorticoid Receptor Transactivation in Congenital Adrenal Hyperplasia},
  author={Christiaan F. Mooij and Silvia Parajes and Karijn J. Pijnenburg-Kleizen and Wiebke Arlt and Nils P. Krone and Hedi L Claahsen-van der Grinten},
  journal={Hormone Research in Paediatrics},
  year={2015},
  volume={83},
  pages={414 - 421}
}
Background: Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency leads to accumulation of steroid precursors and adrenal androgens. These steroids may have a biological effect on the steroid receptor with clinical consequences on diagnostics and treatment in CAH patients. Therefore, we analysed the effect of accumulated steroids [17-hydroxyprogesterone (17OHP), progesterone, androstenedione and testosterone] on aldosterone-mediated transactivation of the human mineralocorticoid… 

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