Influence of 16S ribosomal RNA gene polymerase chain reaction and sequencing on antibiotic management of bone and joint infections.


INTRODUCTION Amplification of the 16S ribosomal RNA gene by polymerase chain reaction (PCR) followed by analysis of generated sequences can be an important adjunct to conventional cultures. OBJECTIVE To determine how the results of this approach influence physicians' decisions regarding the management of bone and joint infections. METHOD Clinical and… (More)


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