Influence of 1,25-Dihydroxyvitamin D3on Cultured Osteogenic Sarcoma Cells: Correlation with the 1,25-Dihydroxyvitamin D3Receptor1


We have characterized the effects of the steroid hormone 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] on a series of rat osteogenic sarcoma cell lines of increasing osteoblastic-like nature (ROS 24/1, ROS 2/3, and ROS 17/2.8). When these cells were grown in monolayer culture in the presence of 10 nw 1,25(OH)2D3, there was a dramatic and selective inhibition of… (More)


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