Influence and pathophysiological mechanisms of simvastatin on prostatic hyperplasia in spontaneously hypertensive rats.

@article{Zhang2013InfluenceAP,
  title={Influence and pathophysiological mechanisms of simvastatin on prostatic hyperplasia in spontaneously hypertensive rats.},
  author={Xiangyu Zhang and Fang Shen and Lini Dong and Xiaokun Zhao and Xiao-Bing Qu},
  journal={Urologia internationalis},
  year={2013},
  volume={91 4},
  pages={467-73}
}
OBJECTIVE To explore the effects and mechanisms of simvastatin on prostate hyperplasia in spontaneously hypertensive rats (SHRs). METHODS Thirty-six male SHRs were randomly divided into three groups: the 10 and the 20 mg/kg/d simvastatin group and the control group. After 6 weeks the ultra-microscopic prostate structures were observed. The serum levels of interleukin-6 (IL-6), insulin-like growth factor (IGF-1) and angiotensin II (Ang-II) were measured by enzyme-linked immunosorbent assays… CONTINUE READING

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Reproduced with the permission

AG S.Karger, Basel
2013

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