Infliximab in combination with methotrexate in active ankylosing spondylitis: a clinical and imaging study.

@article{MarzoOrtega2005InfliximabIC,
  title={Infliximab in combination with methotrexate in active ankylosing spondylitis: a clinical and imaging study.},
  author={Helena Marzo-Ortega and Dennis McGonagle and Stephanie Therese Jarrett and Glenn Haugeberg and Elizabeth M. A. Hensor and Philip J O'connor and Ai Lyn Tan and Philip Gerard Conaghan and Anat Greenstein and Paul Emery},
  journal={Annals of the rheumatic diseases},
  year={2005},
  volume={64 11},
  pages={
          1568-75
        }
}
OBJECTIVE To examine the efficacy and safety of infliximab combined with methotrexate compared with methotrexate alone in the treatment of ankylosing spondylitis (AS) using MRI and DXA to monitor its impact on bone. METHODS In this single centre study 42 subjects with active AS were treated with methotrexate and were randomly assigned, in a ratio of 2:1, to receive five infusions of either 5 mg/kg infliximab or placebo over 30 weeks. The primary outcome was improvement in disease activity as… CONTINUE READING

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Infliximab in the treatment of ankylosing spondylitis

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