Infliximab as rescue therapy in severe to moderately severe ulcerative colitis: a randomized, placebo-controlled study.

@article{Jrnerot2005InfliximabAR,
  title={Infliximab as rescue therapy in severe to moderately severe ulcerative colitis: a randomized, placebo-controlled study.},
  author={Gunnar J{\"a}rnerot and Erik Hertervig and Ingalill Friis-Liby and Lars Blomquist and Per Karl{\'e}n and Christer Gr{\"a}nn{\"o} and Mogens Vili{\'e}n and Magnus Str{\"o}m and Ake Danielsson and Hans P Verbaan and Per M Hellstr{\"o}m and Anders Magnuson and Bengt Curman},
  journal={Gastroenterology},
  year={2005},
  volume={128 7},
  pages={1805-11}
}
BACKGROUND & AIMS Despite treatment with corticosteroids, severe to moderately severe attacks of ulcerative colitis have a high colectomy rate. We intended to find a rescue therapy other than cyclosporin A, which imposes a high risk of side effects and cyclosporine-related mortality. METHODS This was a randomized double-blind trial of infliximab or placebo in severe to moderately severe ulcerative colitis not responding to conventional treatment. Patients were randomized to infliximab/placebo… CONTINUE READING
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