Infliximab "Top-Down" Strategy is Superior to "Step-Up" in Maintaining Long-Term Remission in the Treatment of Pediatric Crohn Disease.

@article{Lee2015InfliximabS,
  title={Infliximab "Top-Down" Strategy is Superior to "Step-Up" in Maintaining Long-Term Remission in the Treatment of Pediatric Crohn Disease.},
  author={Yoo Min Lee and Ben Kang and Yoon Lee and Mi Jin Kim and Yon Ho Choe},
  journal={Journal of pediatric gastroenterology and nutrition},
  year={2015},
  volume={60 6},
  pages={
          737-43
        }
}
OBJECTIVES We aimed to compare the efficacy of remission maintenance between infliximab "top-down" and "step-up" strategies in moderate to severe pediatric Crohn disease during 3 years. We also aimed to determine prognostic factors that may influence the relapse-free rate in these patients. METHODS The present study was a retrospective review of a prospective cohort, based on an infliximab treatment protocol for pediatric Crohn disease used at Samsung Medical Center. A total of 31 patients… CONTINUE READING
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