Infliximab, azathioprine, or combination therapy for Crohn's disease.

  title={Infliximab, azathioprine, or combination therapy for Crohn's disease.},
  author={Jean Fr{\'e}d{\'e}ric Colombel and W J Sandborn and Walter Reinisch and Gerassimos Mantzaris and Asher A Kornbluth and Daniel Rachmilewitz and Simon Lichtiger and G D'Haens and Robert H Diamond and Delma L Broussard and Kezhen L. Tang and Christien Janneke van der Woude and P. R. Rutgeerts},
  journal={The New England journal of medicine},
  volume={362 15},
BACKGROUND The comparative efficacy and safety of infliximab and azathioprine therapy alone or in combination for Crohn's disease are unknown. METHODS In this randomized, double-blind trial, we evaluated the efficacy of infliximab monotherapy, azathioprine monotherapy, and the two drugs combined in 508 adults with moderate-to-severe Crohn's disease who had not undergone previous immunosuppressive or biologic therapy. Patients were randomly assigned to receive an intravenous infusion of 5 mg… CONTINUE READING
Highly Influential
This paper has highly influenced 48 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 820 extracted citations


Publications referenced by this paper.
Showing 1-10 of 30 references

Efficacy and safety of tumor necrosis antagonists in Crohn ’ s disease : a meta - analysis of placebo - controlled trials

  • WR Best, JM Becktel, JW Singleton, F Kern
  • Clin Gastroenterol Hepatol
  • 2008

Similar Papers

Loading similar papers…