Inflammatory tumour cell killing by oncolytic reovirus for the treatment of melanoma

@article{Errington2008InflammatoryTC,
  title={Inflammatory tumour cell killing by oncolytic reovirus for the treatment of melanoma},
  author={Fiona Errington and Christine L. White and Katie R Twigger and Adam Rose and K Scott and Lynette P. Steele and Liz Ilett and Robin J D Prestwich and Hardev S. Pandha and Matthew C. Coffey and Peter John Selby and Richard G. Vile and Kevin J. Harrington and Alan A Melcher},
  journal={Gene Therapy},
  year={2008},
  volume={15},
  pages={1257-1270}
}
Reovirus is a promising unmodified double-stranded RNA (dsRNA) anti-cancer oncolytic virus, which is thought to specifically target cells with activated Ras. Although reovirus has been tested in a wide range of preclinical models and has entered early clinical trials, it has not previously been tested for the treatment of human melanoma. Here, we show that reovirus effectively kills and replicates in both human melanoma cell lines and freshly resected tumour; intratumoural injection also causes… CONTINUE READING

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