Inflammatory stimuli regulate caspase substrate profiles.

  title={Inflammatory stimuli regulate caspase substrate profiles.},
  author={Nicholas J. Agard and David T. Maltby and James A. Wells},
  journal={Molecular & cellular proteomics : MCP},
  volume={9 5},
The inflammatory caspases, human caspases-1, -4, and -5, proteolytically modulate diverse physiological outcomes in response to proinflammatory signals. Surprisingly, only a few substrates are known for these enzymes, including other caspases and the interleukin-1 family of cytokines. To more comprehensively characterize inflammatory caspase substrates, we combined an enzymatic N-terminal enrichment method with mass spectrometry-based proteomics to identify newly cleaved proteins. Analysis of… CONTINUE READING