Inflammatory status influences aromatase and steroid receptor expression in endometriosis.

@article{Bukulmez2008InflammatorySI,
  title={Inflammatory status influences aromatase and steroid receptor expression in endometriosis.},
  author={Orhan Bukulmez and Daniel B Hardy and Bruce Richard Carr and R Ann Word and Carole R. Mendelson},
  journal={Endocrinology},
  year={2008},
  volume={149 3},
  pages={1190-204}
}
Aberrant up-regulation of aromatase in eutopic endometrium and implants from women with endometriosis has been reported. Aromatase induction may be mediated by increased cyclooxygenase-2 (COX-2). Recently, we demonstrated that progesterone receptor (PR)-A and PR-B serve an antiinflammatory role in the uterus by antagonizing nuclear factor kappaB activation and COX-2 expression. PR-C, which antagonizes PR-B, is up-regulated by inflammation. Although estrogen receptor alpha (ERalpha) is… CONTINUE READING
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