Inflammatory signatures for eosinophilic vs. neutrophilic allergic pulmonary inflammation reveal critical regulatory checkpoints.

@article{Bogaert2011InflammatorySF,
  title={Inflammatory signatures for eosinophilic vs. neutrophilic allergic pulmonary inflammation reveal critical regulatory checkpoints.},
  author={Pieter Bogaert and Thomas Naessens and Stefaan De Koker and Benoit Hennuy and Jonathan Hacha and Muriel Smet and Didier Cataldo and Emmanuel Di Valentin and Jacques Piette and Kurt G. Tournoy and Johan Grooten},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2011},
  volume={300 5},
  pages={L679-90}
}
Contrary to the T-helper (Th)-2 bias and eosinophil-dominated bronchial inflammation encountered in most asthmatic subjects, other patients may exhibit neutrophil-predominant asthma subphenotypes, along with Th-1 and Th-17 cells. However, the etiology of many neutrophil-dominated asthma subphenotypes remains ill-understood, in part due to a lack of appropriate experimental models. To better understand the distinct immune-pathological features of eosinophilic vs. neutrophilic asthma types, we… CONTINUE READING