Inflammatory signals direct expression of human IL12RB1 into multiple distinct isoforms.

@article{Ford2012InflammatorySD,
  title={Inflammatory signals direct expression of human IL12RB1 into multiple distinct isoforms.},
  author={Nicole R. Ford and Halli Miller and Allison E Reeme and Jill K. Waukau and Christine E Bengtson and John M. Routes and Richard T Robinson},
  journal={Journal of immunology},
  year={2012},
  volume={189 9},
  pages={4684-94}
}
IL12RB1 is essential for human resistance to multiple intracellular pathogens, including Mycobacterium tuberculosis. In its absence, the proinflammatory effects of the extracellular cytokines IL-12 and IL-23 fail to occur, and intracellular bacterial growth goes unchecked. Given the recent observation that mouse leukocytes express more than one isoform from il12rb1, we examined whether primary human leukocytes similarly express more than one isoform from IL12RB1. We observed that human… CONTINUE READING

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