Inflammatory responses and inflammation-associated diseases in organs

  title={Inflammatory responses and inflammation-associated diseases in organs},
  author={Linlin Chen and Huidan Deng and Hengmin Cui and Jing Fang and Zhicai Zuo and Junliang Deng and Yinglun Li and Xun Wang and Ling Zhao},
  pages={7204 - 7218}
Inflammation is a biological response of the immune system that can be triggered by a variety of factors, including pathogens, damaged cells and toxic compounds. These factors may induce acute and/or chronic inflammatory responses in the heart, pancreas, liver, kidney, lung, brain, intestinal tract and reproductive system, potentially leading to tissue damage or disease. Both infectious and non-infectious agents and cell damage activate inflammatory cells and trigger inflammatory signaling… 

Figures and Tables from this paper

Epidemiology of Inflammation-Related Diseases

  • Kevser Tarı Selçuk
  • Medicine
  • 2020
Chronic inflammation instigates various kinds of diseases that cause premature mortality and morbidity such us cardiovascular diseases, cancer, diabetes mellitus, asthma-chronic obstructive pulmonary disease, obesity, metabolic syndrome (METs), inflammatory bowel disease (IBD), rheumatoid arthritis, multiple sclerosis, osteoporosis, and neurological diseases via dysregulation of various signaling pathways.

Inflammation in Focus: The Beginning and the End

The attention is drawn to the long-lasting consequence of chronic inflammation, pointing out that one of the most important step in medication is to identify in time the factors initiating and maintaining inflammation.

Inflammation: improving understanding to prevent or ameliorate kidney diseases

Some inflammatory molecules can be useful biomarkers for the detection and diagnosis of kidney diseases, such as neutrophil gelatinase-associated lipocalin, kidney injury molecule-1 and interleukin 18.

Regulation of Inflammatory Reaction in Health and Disease

Bioregulatory systems medicine (BrSM) and low dose medicine (LDM), two pharmacological paradigms grounded in systems medicine, potentially represent new tools for the treatment of inflammation-related diseases.

Roles of Resolvins in Chronic Inflammatory Response

By promoting the inflammation resolution, resolvins play an irreplaceable role throughout the pathological process of some joint inflammation, neuroinflammation, vascular inflammation, and tissue inflammation.

The Extracellular MicroRNAs on Inflammation: A Literature Review of Rodent Studies

Diverse EV-associated miRNAs regulate inflammasome activation and pro- and anti-inflammatory cytokine levels by targeting genes, and play a key role in various diseases, including organ injury, immune dysfunction, neurological disease, metabolic syndrome, vesicular disease, arthritis, cancer, and other inflammatory diseases.

Retinoic Acid-Induced Regulation of Inflammatory Pathways Is a Potential Sepsis Treatment

It is proposed that all-trans-retinoic acid (RA) may increase the function of native regulatory pathways and serve as a novel treatment for sepsis.

Chronic Inflammatory Diseases, Anti-Inflammatory Agents and Their Delivery Nanosystems

This contribution summarizes the current state of research and development of nanoformulated anti-inflammatory agents from both conventional drug classes and experimental drugs or dietary supplements used to alleviate inflammatory reactions.

Phytochemicals as Anti-Inflammatory Agents in Animal Models of Prevalent Inflammatory Diseases

The characteristics of phytochemicals that possess anti- inflammatory activities in various chronic inflammatory diseases are discussed and the molecular signaling pathways altered by these anti-inflammatory phytochemical mechanisms are reviewed, with a focus on transcription factor pathways.



Innate immune response and hepatic inflammation.

The specificity of Toll-like receptors and the mechanisms of innate immune cell activation are discussed in relation to acute and chronic liver injury including viral, alcoholic, nonalcoholic, and drug-induced hepatitis.

Inflammatory mechanisms: the molecular basis of inflammation and disease.

  • P. Libby
  • Biology, Medicine
    Nutrition reviews
  • 2007
Inflammation participates importantly in host defenses against infectious agents and injury, but it also contributes to the pathophysiology of many chronic diseases. Interactions of cells in the

T Cells in Vascular Inflammatory Diseases

Evidence supporting the role of different T cell subsets in vascular inflammation is described and selected targeting of pathogenic TEM cells might enable a more tailored therapeutic approach that avoids unwanted adverse side effects of generalized immunosuppression.

STAT6 and lung inflammation

This review will focus on the role of STAT6 in lung diseases and mechanisms by which STAT6 controls immune and structural lung cell function.

Key mechanisms governing resolution of lung inflammation

This review will summarise the major mechanisms regulating lung inflammation, including key cellular interplays such as apoptotic cell clearance by alveolar macrophages and macrophage/neutrophil/epithelial cell interactions.

Innate immune recognition in infectious and noninfectious diseases of the lung.

The PRR engagement is the prerequisite for the initiation of immune responses to infections and tissue injuries which can be beneficial or detrimental to the host.

Decoding cell death signals in liver inflammation.

Inflammatory pathways in female reproductive health and disease.

The role of inflammatory events in normal reproductive function and its pathologies is addressed and specific biochemical events are activated to re-establish homeostasis in the affected tissue.

Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses.

  • A. Beg
  • Biology
    Trends in immunology
  • 2002