Inflammatory responses and inflammation-associated diseases in organs

@article{Chen2018InflammatoryRA,
  title={Inflammatory responses and inflammation-associated diseases in organs},
  author={Linlin Chen and Huidan Deng and Hengmin Cui and Jing Fang and Zhicai Zuo and Junliang Deng and Yinglun Li and Xun Wang and Ling Zhao},
  journal={Oncotarget},
  year={2018},
  volume={9},
  pages={7204 - 7218}
}
Inflammation is a biological response of the immune system that can be triggered by a variety of factors, including pathogens, damaged cells and toxic compounds. These factors may induce acute and/or chronic inflammatory responses in the heart, pancreas, liver, kidney, lung, brain, intestinal tract and reproductive system, potentially leading to tissue damage or disease. Both infectious and non-infectious agents and cell damage activate inflammatory cells and trigger inflammatory signaling… 

Figures and Tables from this paper

Epidemiology of Inflammation-Related Diseases

TLDR
Chronic inflammation instigates various kinds of diseases that cause premature mortality and morbidity such us cardiovascular diseases, cancer, diabetes mellitus, asthma-chronic obstructive pulmonary disease, obesity, metabolic syndrome (METs), inflammatory bowel disease (IBD), rheumatoid arthritis, multiple sclerosis, osteoporosis, and neurological diseases via dysregulation of various signaling pathways.

Inflammation in Focus: The Beginning and the End

TLDR
The attention is drawn to the long-lasting consequence of chronic inflammation, pointing out that one of the most important step in medication is to identify in time the factors initiating and maintaining inflammation.

Inflammation: improving understanding to prevent or ameliorate kidney diseases

TLDR
Some inflammatory molecules can be useful biomarkers for the detection and diagnosis of kidney diseases, such as neutrophil gelatinase-associated lipocalin, kidney injury molecule-1 and interleukin 18.

Regulation of Inflammatory Reaction in Health and Disease

TLDR
Bioregulatory systems medicine (BrSM) and low dose medicine (LDM), two pharmacological paradigms grounded in systems medicine, potentially represent new tools for the treatment of inflammation-related diseases.

The Extracellular MicroRNAs on Inflammation: A Literature Review of Rodent Studies

TLDR
Diverse EV-associated miRNAs regulate inflammasome activation and pro- and anti-inflammatory cytokine levels by targeting genes, and play a key role in various diseases, including organ injury, immune dysfunction, neurological disease, metabolic syndrome, vesicular disease, arthritis, cancer, and other inflammatory diseases.

Chronic Inflammatory Diseases, Anti-Inflammatory Agents and Their Delivery Nanosystems

TLDR
This contribution summarizes the current state of research and development of nanoformulated anti-inflammatory agents from both conventional drug classes and experimental drugs or dietary supplements used to alleviate inflammatory reactions.

Phytochemicals as Anti-Inflammatory Agents in Animal Models of Prevalent Inflammatory Diseases

TLDR
The characteristics of phytochemicals that possess anti- inflammatory activities in various chronic inflammatory diseases are discussed and the molecular signaling pathways altered by these anti-inflammatory phytochemical mechanisms are reviewed, with a focus on transcription factor pathways.

Acute Inflammatory Response

TLDR
This article will discuss "acute inflammation" which occurs immediately after injury and lasts for few days, chronic inflammation that may last for months or even years when acute inflammation fails to settle and subacute which is a transformational period from acute to chronic which lasts from 2 to 6 weeks.
...

References

SHOWING 1-10 OF 165 REFERENCES

Innate immune response and hepatic inflammation.

TLDR
The specificity of Toll-like receptors and the mechanisms of innate immune cell activation are discussed in relation to acute and chronic liver injury including viral, alcoholic, nonalcoholic, and drug-induced hepatitis.

Inflammatory mechanisms: the molecular basis of inflammation and disease.

  • P. Libby
  • Biology, Medicine
    Nutrition reviews
  • 2007
Inflammation participates importantly in host defenses against infectious agents and injury, but it also contributes to the pathophysiology of many chronic diseases. Interactions of cells in the

T Cells in Vascular Inflammatory Diseases

TLDR
Evidence supporting the role of different T cell subsets in vascular inflammation is described and selected targeting of pathogenic TEM cells might enable a more tailored therapeutic approach that avoids unwanted adverse side effects of generalized immunosuppression.

Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.

Macrophages in inflammation.

TLDR
Because macrophages produce a wide range of biologically active molecules participated in both beneficial and detrimental outcomes in inflammation, therapeutic interventions targeted macrophage and their products may open new avenues for controlling inflammatory diseases.

Key mechanisms governing resolution of lung inflammation

TLDR
This review will summarise the major mechanisms regulating lung inflammation, including key cellular interplays such as apoptotic cell clearance by alveolar macrophages and macrophage/neutrophil/epithelial cell interactions.

Innate immune recognition in infectious and noninfectious diseases of the lung.

TLDR
The PRR engagement is the prerequisite for the initiation of immune responses to infections and tissue injuries which can be beneficial or detrimental to the host.

Stress molecules in sepsis and systemic inflammatory response syndrome

Decoding cell death signals in liver inflammation.

...