Inflammatory response of human tendon fibroblasts to cyclic mechanical stretching.

BACKGROUND The cellular and molecular mechanisms for the development of tendinopathy are not clear, but inflammatory mediators produced by tendon fibroblasts in response to repetitive mechanical loading may be an important factor. HYPOTHESES (1) Cyclic stretching of tendon fibroblasts affects the production of leukotriene B(4) and the expression of 5… (More)