Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: age-dependent switch in the microglial phenotype from alternative to classic.

@article{Jimnez2008InflammatoryRI,
  title={Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: age-dependent switch in the microglial phenotype from alternative to classic.},
  author={Sebasti{\'a}n Jim{\'e}nez and David Baglietto-Vargas and Cristina Caballero and In{\'e}s Moreno-Gonz{\'a}lez and Manuel Torres and Raquel S{\'a}nchez-Varo and Diego Ruano and Marisa Vizuete and Antonia Gutierrez and Javier Vitorica},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2008},
  volume={28 45},
  pages={11650-61}
}
Although the microglial activation is concomitant to the Alzheimer's disease, its precise role (neuroprotection vs neurodegeneration) has not yet been resolved. Here, we show the existence of an age-dependent phenotypic change of microglial activation in the hippocampus of PS1xAPP model, from an alternative activation state with Abeta phagocytic capabilities (at 6 months) to a classic cytotoxic phenotype (expressing TNF-alpha and related factors) at 18 months of age. This switch was coincident… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
136 Citations
71 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 136 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 71 references

Inter - individual variability in the expression of the mutated form of hPS 1 M 146 L determined the production of Abeta peptides in the PS 1 xAPP transgenic mice

  • C Caballero, S Jimenez, +9 authors J Vitorica
  • J Neurosci Res
  • 2007
Highly Influential
5 Excerpts

Dynamics of the microglial/amyloid

  • M Jucker, ME Calhoun
  • 2008

Similar Papers

Loading similar papers…