Inflammatory response following intranasal infection with Mycobacterium avium complex: role of T-cell subsets and gamma interferon.

@article{Saunders1995InflammatoryRF,
  title={Inflammatory response following intranasal infection with Mycobacterium avium complex: role of T-cell subsets and gamma interferon.},
  author={Bernadette M. Saunders and Christina Cheers},
  journal={Infection and immunity},
  year={1995},
  volume={63 6},
  pages={
          2282-7
        }
}
The role of CD4+ and CD8+ T cells in the response to intranasal infection with a Mycobacterium avium complex isolate (MAC) was investigated. Depletion of CD4+ T cells by injected antibody exacerbated infection in the lung, spleen, and liver. There were decreased numbers of inflammatory cells in the lungs of CD4-depleted mice and a significant decrease in lung cytotoxic activity. The neutrophil response was unaffected, and in CD4-depleted mice, unlike intact infected mice, these cells were found… CONTINUE READING

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