Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells.

@article{Niwa2010InflammatoryPT,
  title={Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells.},
  author={Tohru Niwa and Tetsuya Tsukamoto and Takeshi Toyoda and Akiko Mori and Harunari Tanaka and Takao Maekita and Masao Ichinose and Masae Tatematsu and Toshikazu Ushijima},
  journal={Cancer research},
  year={2010},
  volume={70 4},
  pages={1430-40}
}
Altered patterns of DNA methylation associated with Helicobacter pylori (HP) infection of gastric epithelial cells are thought to contribute to gastric cancer risk. However, it is unclear whether this increased risk reflects an infection-associated inflammatory response or the infection itself. In this study, we sought to clarify mechanisms in a gerbil model of gastric cancer where we showed that HP infection is causally involved in induction of aberrant DNA methylation. By genome-wide… CONTINUE READING

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