Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells

@article{Prasad2005InflammatoryPH,
  title={Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells},
  author={S. Prasad and R. Mingrino and K. Kaukinen and K. L. Hayes and R. Powell and T. Macdonald and J. Collins},
  journal={Laboratory Investigation},
  year={2005},
  volume={85},
  pages={1139-1162}
}
Claudin proteins comprise a recently described family of tight junction proteins that differentially regulate paracellular permeability. Since other tight junction proteins show alterations in distribution or expression in inflammatory bowel disease (IBD) we assessed expression of claudins (CL) 2, 3 and 4 in IBD. CL 2 was strongly expressed along the inflamed crypt epithelium, whilst absent or barely detectable in normal colon. In contrast, CL 3 and 4 were present throughout normal colonic… Expand
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