Inflammatory process in murine lymphocytic choriomeningitis is maximal in H-2K or H-2D compatible interactions.

@article{Doherty1976InflammatoryPI,
  title={Inflammatory process in murine lymphocytic choriomeningitis is maximal in H-2K or H-2D compatible interactions.},
  author={Patrick C. Doherty and Malcolm Benson Critchley Dunlop and Christopher Richard Parish and Rolf Martin Zinkernagel},
  journal={Journal of immunology},
  year={1976},
  volume={117 1},
  pages={
          187-90
        }
}
Capacity to transfer adoptively fatal lymphocytic choriomeningitis (LCM) to immunosuppressed, virus-infected recipients is a property of H-2 compatible, non-Ig-bearing virus-immune lymphocytes. Severe meningitis is recognized when donor and recipient share at least one allele at either H-2K or H-2D. Presence of unshared H-2 genes is not obviously inhibitory, and identity at the immune response (Ir) region of the H-2 gene complex is neither sufficient nor necessary. The same constraint applies… CONTINUE READING

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