Inflammatory myofibroblastic tumors harbor multiple potentially actionable kinase fusions.

@article{Lovly2014InflammatoryMT,
  title={Inflammatory myofibroblastic tumors harbor multiple potentially actionable kinase fusions.},
  author={Christine M Lovly and Abha A Gupta and Doron M Lipson and Geoff A. Otto and Tina Brennan and Catherine T-S Chung and Scott C Borinstein and Jeffrey S. Ross and Philip J. Stephens and Vincent A. Miller and Cheryl M. Coffin},
  journal={Cancer discovery},
  year={2014},
  volume={4 8},
  pages={889-95}
}
UNLABELLED Inflammatory myofibroblastic tumor (IMT) is a neoplasm that typically occurs in children. The genetic landscape of this tumor is incompletely understood and therapeutic options are limited. Although 50% of IMTs harbor anaplastic lymphoma kinase (ALK) rearrangements, no therapeutic targets have been identified in ALK-negative tumors. We report for the first time that IMTs harbor other actionable targets, including ROS1 and PDGFRβ fusions. We detail the case of an 8-year-old boy with… CONTINUE READING