Inflammatory mediators in the frontal lobe of patients with mixed and vascular dementia.

Abstract

Vascular dementia (VaD) accounts for about 20% of all dementias, and vascular risk is a key factor in more than 40% of people with Alzheimer's disease (AD). Little is known about inflammatory processes in the brains of these individuals. We have examined inflammatory mediators (interleukin (IL)-1beta, IL-1alpha, IL-6 and tumour necrosis factor alpha) and chemokines (macrophage inflammatory protein 1, monocyte chemo-attractant protein (MCP)-1 and granulocyte macrophage colony-stimulating factor) in brain homogenates from grey and white matter of the frontal cortex (Brodmann area 9) from patients with VaD (n = 11), those with concurrent VaD and AD (mixed dementia; n = 8) and from age-matched controls (n = 13) using ELISA assays. We found a dramatic reduction of MCP-1 levels in the grey matter in VaD and mixed dementia in comparison to controls (55 and 66%, respectively). IL-6 decreases were also observed in the grey matter of VaD and mixed dementia (72 and 71%, respectively), with a more modest decrease (30%) in the white matter of patients with VaD or mixed dementia. In the first study to examine the status of inflammatory mediators in a brain region severely affected by white-matter lesions, our findings highlight - in contrast to previous reports in AD - that patients at the later stage of VaD or mixed dementia have a significantly attenuated neuro-inflammatory response.

DOI: 10.1159/000118633

3 Figures and Tables

0200400200920102011201220132014201520162017
Citations per Year

622 Citations

Semantic Scholar estimates that this publication has 622 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Mulugeta2008InflammatoryMI, title={Inflammatory mediators in the frontal lobe of patients with mixed and vascular dementia.}, author={Ezra Mulugeta and Francisco Molina-Holgado and Mark S J Elliott and Tibor Hortob{\'a}gyi and Robert H . Perry and Rajesh N. Kalaria and Clive G. Ballard and Paul Francis}, journal={Dementia and geriatric cognitive disorders}, year={2008}, volume={25 3}, pages={278-86} }