Inflammatory mediators in the frontal lobe of patients with mixed and vascular dementia.


Vascular dementia (VaD) accounts for about 20% of all dementias, and vascular risk is a key factor in more than 40% of people with Alzheimer's disease (AD). Little is known about inflammatory processes in the brains of these individuals. We have examined inflammatory mediators (interleukin (IL)-1beta, IL-1alpha, IL-6 and tumour necrosis factor alpha) and chemokines (macrophage inflammatory protein 1, monocyte chemo-attractant protein (MCP)-1 and granulocyte macrophage colony-stimulating factor) in brain homogenates from grey and white matter of the frontal cortex (Brodmann area 9) from patients with VaD (n = 11), those with concurrent VaD and AD (mixed dementia; n = 8) and from age-matched controls (n = 13) using ELISA assays. We found a dramatic reduction of MCP-1 levels in the grey matter in VaD and mixed dementia in comparison to controls (55 and 66%, respectively). IL-6 decreases were also observed in the grey matter of VaD and mixed dementia (72 and 71%, respectively), with a more modest decrease (30%) in the white matter of patients with VaD or mixed dementia. In the first study to examine the status of inflammatory mediators in a brain region severely affected by white-matter lesions, our findings highlight - in contrast to previous reports in AD - that patients at the later stage of VaD or mixed dementia have a significantly attenuated neuro-inflammatory response.

DOI: 10.1159/000118633

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@article{Mulugeta2008InflammatoryMI, title={Inflammatory mediators in the frontal lobe of patients with mixed and vascular dementia.}, author={Ezra Mulugeta and Francisco Molina-Holgado and Mark S J Elliott and Tibor Hortob{\'a}gyi and Robert H . Perry and Rajesh N. Kalaria and Clive G. Ballard and Paul Francis}, journal={Dementia and geriatric cognitive disorders}, year={2008}, volume={25 3}, pages={278-86} }