Inflammatory mediators in a short-time mouse model of doxorubicin-induced cardiotoxicity.

Abstract

Doxorubicin (DOXO) is commonly used to treat a wide range of malignant tumors, but its clinical use is limited by acute and chronic cardiotoxicity. The precise mechanism underlying DOXO-induced cardiotoxicity is still not completely elucidated, but cardiac inflammation seems to be involved. Effects of DOXO on proinflammatory cytokines, inflammatory cell… (More)
DOI: 10.1016/j.taap.2016.01.006

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