Inflammatory mediators and nuclear receptor signaling in colorectal cancer.

@article{Wang2007InflammatoryMA,
  title={Inflammatory mediators and nuclear receptor signaling in colorectal cancer.},
  author={Dingzhi Wang and Raymond N. Dubois},
  journal={Cell cycle},
  year={2007},
  volume={6 6},
  pages={
          682-5
        }
}
Long-term use of cyclooxygenase (COX) inhibitors (NSAIDs) in humans leads to a 50% reduction in risk for colorectal cancer. However, prolonged use of COX-2 selective inhibitors (coxibs) increases cardiovascular toxicity in some individuals, which highlights the importance of identifying all of the molecular targets that drive progression of colorectal cancer. Colorectal cancer offers a unique model to study the synergistic induction of intestinal neoplasia via dysregulation of multiple… CONTINUE READING
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