Inflammatory lipid sphingosine-1-phosphate upregulates C-reactive protein via C/EBPβ and potentiates breast cancer progression

@article{Kim2014InflammatoryLS,
  title={Inflammatory lipid sphingosine-1-phosphate upregulates C-reactive protein via C/EBPβ and potentiates breast cancer progression},
  author={E Kim and Yujin Cha and Mina Ham and J Jung and Sang Gyun Kim and S Hwang and Robert Kleemann and Aree Moon},
  journal={Oncogene},
  year={2014},
  volume={33},
  pages={3583-3593}
}
A crucial role of the inflammatory lipid sphingosine-1-phosphate (S1P) in breast cancer aggressiveness has been reported. Recent clinical studies have suggested that C-reactive protein (CRP) has a role in breast cancer development. However, limited information is available on the molecular basis for the expression of CRP and its functional significance in breast cell invasion. The present study aimed to elucidate the molecular link between S1P and CRP during the invasive process of breast… CONTINUE READING