Inflammatory lesions localized with technetium Tc 99m-labeled leukocytes.

  title={Inflammatory lesions localized with technetium Tc 99m-labeled leukocytes.},
  author={B. Andersen and D. English and H. Akalın and W. Henderson},
  journal={Archives of internal medicine},
  volume={135 8},
Canine leukocytes were labeled with a gamma-ray emitting isotope by permitting them to phagocytize technetium Tc 99m sulfur colloid particles in vitro and removing the unphagocytized particles by washing the cells. The labeled cells were reinfused intravenously into the donor dogs. Scintigraphic scans were performed 4 and 24 hours following the leukocyte infusion. In animals with sterile and infected intramuscular abscesses and pulmonary infections, it was possible to localize the lesions by… Expand
16 Citations
Indium 111 oxine-labeled leukocytes for early diagnosis of ischemic enterocolitis.
These studies demonstrate that 111In oxine-labeled autologous white blood cells can be used for the diagnosis of ischemic enterocolitis in vivo and show a correlation between the area of infarction and tracer accumulation. Expand
In vitro labeling of human polymorphonuclear leukocytes with 99mTc
Preliminary experience with 99mTc labeling of isolated polymorphonuclear leukocytes is reported and may prove a valuable alternative for assessment of local leukocyte accumulation by scintigraphy. Expand
Neutrophil labeling: problems and pitfalls.
The use of neutrophils labeled with gamma-emitting radionuclides has been shown to be acceptable for in vivo kinetic studies as well as for imaging inflammatory foci, and the current research aimed at eliminating the problems is outlined. Expand
Role of gallium 67 in inflammatory disease.
Gallium 67 has been found to be extremely useful for detection of inflammatory disease and complements the 99m Tc-phosphate compounds in differentiating periatricular osteomyelitis, septic arthritis, and cellulitis. Expand
Labeled cells in patients with malignancy.
  • J. Dutcher
  • Medicine
  • Seminars in nuclear medicine
  • 1984
The major value in patients with malignancy, primarily with hematologic malignancies, is to evaluate the potential benefit of granulocyte transfusions, and an area of much interest in the use of indium-111 is the labeling ofgranulocytes. Expand
Identification of factors affecting technetium 99m leucocyte labelling by phagocytic engulfment and evelopment of an optimal technique
Human autologous leucocytes can be simply and reproducibly labelled by phagocytic engulfment of technetium 99m stannous colloid with high leucocyte-labelling efficiency (LLE) and consistent labelling efficiencies in excess of 90% can be obtained with neutrophil predominance. Expand
Imaging Infection with Indium-111-Labeled Leukocytes
The Indium-111 leukocyte scan has now been widely examined as a promising means for imaging focal infection. Expand
Radiolabeled blood cells: techniques and applications.
  • A. Desai, M. Thakur
  • Chemistry, Medicine
  • Critical reviews in clinical laboratory sciences
  • 1986
Experimental and clinical applications of autologous blood cells labeled with gamma-emitting radionuclides aimed at the studies of in vivo cell kinetics and detecting abnormal lesions by external imaging will be discussed. Expand
Radiochemistry and biostability of autologous leucocytes labelled with 99mTc-stannous colloid in whole blood
Results indicate that autologous leucocytes can be efficiently labelled with 99mTc-stannous colloid with good residual cell function and shown in vitro to be viable and maintain normal bactericidal and chemotactic capacity. Expand
Prevention of haemolytic diseases of the newborn due to anti-D.
  • 1981
such as technetium-99m,9 chromium-51,10 and indium1111 may be attached to leucocytes. All these isotopes are gamma emitters, so permitting their detection by camera or rectilinear scanner. GalliumExpand


Labeling of phagocytes from human blood with 99mTc-sulfur colloid.
  • D. English, B. Andersen
  • Medicine
  • Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • 1975
A method by which phagocytic cells can be selectively labeled with 99mTc in amounts suitable for scintillation scanning is offered. Expand
Evidence for granulocytic incorporation of 67gallium in chronic granulocytic leukemia.
The phenomenon of 67 Ga binding by granulocytes provides a valuable method to localize disease in CGL and may prove useful in the study of granulocyte kinetics or in the clinical investigation of occult inflammatory lesions. Expand
The kinetics of 67gallium incorporation into inflammatory lesions: experimental and clinical studies.
The data suggest that scanning with 67 Ga may provide a useful noninvasive technique for the localization of inflammatory lesions in man and are consistent with the hypothesis that localization of 67 Ga within areas of inflammation is chiefly mediated by the binding of the nuclide within granulocytic inflammatory cells. Expand
Pickup of radioactive iodinated albumin by abscesses.
To note if serum albumin tagged with radioactive iodine, if given intravenously, would localize in the abscess, six mongrel dogs were used as the animals. Expand
The delineation of abscesses by scintiphotography using Cr51 labeled leukocytes.
Improved techniques of preparation, labeling and scanning may allow extension of this approach for human patients in whom the presence and location of abscesses may be a diagnostic problem. Expand
Gallium-67 for Localization of Septic Lesions
Abstract Gallium-67 citrate was administered intravenously to 12 septic patients. Gamma camera scintiphotos and rectilinear scans showed focal accumulation of the gallium in 11 of the patients. In ...
In vitro and in vivo labeling of rabbit blood leukocytes with 67Ga-citrate.