Inflammatory intrathecal profiles and cortical damage in multiple sclerosis

@article{Magliozzi2018InflammatoryIP,
  title={Inflammatory intrathecal profiles and cortical damage in multiple sclerosis},
  author={Roberta Magliozzi and Owain W. Howell and Richard S. Nicholas and Carolina Cruciani and Marco Castellaro and Chiara Romualdi and Stefania Rossi and Marco Pitteri and Maria Donata Benedetti and Alberto Gajofatto and Francesca Benedetta Pizzini and Stefania Montemezzi and Sarah Rasia and Ruggero Capra and Alessandra Bertoldo and Francesco Facchiano and Salvatore Monaco and Richard Reynolds and Massimiliano Calabrese},
  journal={Annals of Neurology},
  year={2018},
  volume={83}
}
Gray matter (GM) damage and meningeal inflammation have been associated with early disease onset and a more aggressive disease course in multiple sclerosis (MS), but can these changes be identified in the patient early in the disease course? 
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148 Citations
Highly Influential Citations
7
Background Citations
50
Methods Citations
9
Results Citations
5

148 Citations

Meningeal inflammation and cortical demyelination in acute multiple sclerosis
TLDR
More is needed to know about how cortical demyelination, neurodegeneration, and meningeal inflammation contribute to pathology at early stages of MS to better predict long‐term outcome.
Cortical Lesions in Multiple Sclerosis and Inflammatory Cytokines in CSF
Patients with multiple sclerosis (MS) are more likely to have early onset aggressive disease if they have grey matter damage and meningeal
A surface‐in gradient of thalamic damage evolves in pediatric multiple sclerosis
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It is assessed how early in the multiple sclerosis course a "surface‐in" process of injury suggesting progressive biology may begin, which reportedly exhibits a gradient of damage from the surface inward.
Cortical and meningeal pathology in progressive multiple sclerosis: a new therapeutic target?
TLDR
The state-of-the-art diagnostic and therapeutic alternatives and the development of strategies to discover new therapeutic approaches are addressed, especially for the progressive forms of multiple sclerosis.
Accumulation of meningeal lymphocytes correlates with white matter lesion activity in progressive multiple sclerosis
TLDR
The findings support the involvement of meningeal lymphocytes in subpial cortical injury and point to a potential link between inflammatory subpial cortex demyelination and pathological mechanisms occurring in the subcortical WM.
Intrathecal Inflammation in Progressive Multiple Sclerosis
TLDR
A comprehensive review on the role of intrathecal inflammation compartmentalized to CNS and non-neural tissues in progressive MS is provided.
Iron homeostasis, complement, and coagulation cascade as CSF signature of cortical lesions in early multiple sclerosis
TLDR
This work aimed to investigate a detailed proteomic CSF profiling which is able to reflect cortical damage in early MS.
Meningeal inflammation changes the balance of TNF signalling in cortical grey matter in multiple sclerosis
TLDR
The inflammatory milieu generated in the subarachnoid space of the multiple sclerosis meninges by infiltrating immune cells leads to increased demyelinating and neurodegenerative pathology in the underlying grey matter due to changes in the balance of TNF signalling.
B cell rich meningeal inflammation associates with increased spinal cord pathology in multiple sclerosis
TLDR
It is shown that the presence of lymphoid‐like structures in the forebrain is associated with a profound spinal cord pathology and local B cell rich meningeal inflammation associates with the extent of cord pathology, which supports a principal role for B cells in sustaining inflammation and tissue injury throughout the CNS in the progressive disease stage.
MRI of cortical lesions and its use in studying their role in MS pathogenesis and disease course
TLDR
It has been proposed that a combined neuropathology, imaging and molecular approach may help to define a more detailed characterization and precise assessment of the heterogeneous features of GM injury and inflammation in MS.
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