Inflammatory interaction between LIGHT and proteinase-activated receptor-2 in endothelial cells: potential role in atherogenesis.

@article{Sandberg2009InflammatoryIB,
  title={Inflammatory interaction between LIGHT and proteinase-activated receptor-2 in endothelial cells: potential role in atherogenesis.},
  author={Wiggo Johan Sandberg and Bente Halvorsen and Arne Yndestad and Camilla Smith and Kari Otterdal and Frank R Brosstad and Stig Sophus Fr\oland and Peder Stefan Olofsson and Jan Kristian Dam{\aa}s and Lars Gullestad and G{\"o}ran K. Hansson and Erik Oie and P{\aa}l Aukrust},
  journal={Circulation research},
  year={2009},
  volume={104 1},
  pages={60-8}
}
The interaction between inflammatory cytokines and endothelial cells is a critical step in atherogenesis leading to endothelial dysfunction and inflammation. We have previously reported that the tumor necrosis factor superfamily member LIGHT could be involved in atherogenesis through its ability to promote vascular inflammation. In the present study we identified proteinase-activated receptor (PAR)-2 as an inflammatory mediator that was markedly enhanced by LIGHT in endothelial cells. We also… CONTINUE READING

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Tumor necrosis factor receptor superfamily 14 is involved in atherogenesis by inducing proinflammatory cytokines and matrix metalloproteinases

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  • Arterioscler Thromb Vasc Biol
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