Inflammatory gene expression in focal cortical brain ischemia: differences between rats and mice.

@article{Schroeter2003InflammatoryGE,
  title={Inflammatory gene expression in focal cortical brain ischemia: differences between rats and mice.},
  author={Michael Schroeter and Patrick K{\"u}ry and Sebastian Jander},
  journal={Brain research. Molecular brain research},
  year={2003},
  volume={117 1},
  pages={
          1-7
        }
}
The impact of species-specific factors on postischemic brain inflammation is largely unknown. In this study, we used quantitative real-time polymerase chain reaction in a highly standardized model of focal cortical brain ischemia for the comparison of cytokine and inducible nitric oxide synthase (iNOS) gene expression in rats and mice. In rats, we found rapid and strong induction of tumor necrosis factor-alpha (TNF-alpha) mRNA reaching its peak at 4 h after ischemia, followed by a slightly… CONTINUE READING

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