Inflammatory disease and cancer with a decrease in Kupffer cell numbers in Nucling-knockout mice.


Nucling is a stress-inducible protein associated with apoptosomes. The cytochrome c-triggered formation of apoptosomes represents a key-initiating event in apoptosis. We have recently reported that Nucling regulates the apoptotic pathway by controlling the activation of NF-kappaB as well. Here we show that hepatocellular carcinoma (HCC) arising… (More)
DOI: 10.1002/ijc.24789


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