Inflammatory demyelination could be attributed to nitric oxide inhibition of cytosolic CoA with failed lipogenesis

@article{Roediger2005InflammatoryDC,
  title={Inflammatory demyelination could be attributed to nitric oxide inhibition of cytosolic CoA with failed lipogenesis},
  author={W. Roediger and G. Gibbons},
  journal={Journal of Neurology},
  year={2005},
  volume={252},
  pages={1418-1419}
}
Sirs: We have observed that prolonged cellular exposure to nitric oxide (NO) inhibits lipogenesis,an action explainable by nitrosation of co-enzyme A (CoA) [1] (Fig. 1). From a number of clinical and experimental observations (see below) we now propose that demyelination of multiple sclerosis and other demyelinating conditions could be due to failure of cell lipogenesis secondary to the action of NO on CoA.The lipid layered structure of the myelin membrane would thereby be impaired [2].NO… Expand

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