Inflammatory cytokines regulate microRNA-155 expression in human retinal pigment epithelial cells by activating JAK/STAT pathway.

@article{Kutty2010InflammatoryCR,
  title={Inflammatory cytokines regulate microRNA-155 expression in human retinal pigment epithelial cells by activating JAK/STAT pathway.},
  author={Rahul Krishnan Kutty and Chandrasekharam N. Nagineni and William M Samuel and Camasamudram Vijayasarathy and John J. Hooks and T Michael Redmond},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={402 2},
  pages={390-5}
}
Inflammatory response of the retinal pigment epithelium plays a critical role in the pathogenesis of retinal degenerative diseases such as age-related macular degeneration. Our previous studies have shown that human retinal pigment epithelial (HRPE) cells, established from adult donor eyes, respond to inflammatory cytokines by enhancing the expression of a number of cytokines and chemokines. To investigate the role of microRNA (miRNA) in regulating this response, we performed microarray… CONTINUE READING
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