Inflammatory cytokines in the pathophysiology of hypertension during preeclampsia.

  title={Inflammatory cytokines in the pathophysiology of hypertension during preeclampsia.},
  author={Babbette LaMarca and M. J. Ryan and Jeffrey S. Gilbert and Sydney R. Murphy and Joey P. Granger},
  journal={Current hypertension reports},
  volume={9 6},
Reduced uterine perfusion pressure during pregnancy is an important initiating event in preeclampsia. Inflammatory cytokines are thought to link placental ischemia with cardiovascular and renal dysfunction. Supporting a role for cytokines are findings of elevated tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 plasma levels in preeclamptic women. Blood pressure regulatory systems (eg, renin-angiotensin system [RAS] and sympathetic nervous system) interact with proinflammatory cytokines… CONTINUE READING


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