Inflammatory cytokines differentially up-regulate human endometrial haptoglobin production in women with endometriosis.

@article{SharpeTimms2010InflammatoryCD,
  title={Inflammatory cytokines differentially up-regulate human endometrial haptoglobin production in women with endometriosis.},
  author={Kathy L. Sharpe-Timms and Henda Nabli and Randy L Zimmer and Julie A. Birt and J. Wade Davis},
  journal={Human reproduction},
  year={2010},
  volume={25 5},
  pages={1241-50}
}
BACKGROUND Evidence suggests that eutopic endometrium from women with endometriosis (US-E) has intrinsic functional anomalies compared with women without endometriosis (US-C). We hypothesized that differences in endometrial haptoglobin (eHp) mRNA and protein levels exist between eutopic endometrium from US-E and US-C and that inflammatory mediators may be involved. METHODS Endometrial stromal cells and tissue explants from US-E (n = 18) and US-C (n = 18) were cultured (24 h/48 h for cells… CONTINUE READING
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