Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus

@article{Simoni2000InflammatoryCA,
  title={Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus},
  author={M. D. De Simoni and C. Perego and T. Ravizza and D. Moneta and M. Conti and Francesco Marchesi and A. De Luigi and S. Garattini and A. Vezzani},
  journal={European Journal of Neuroscience},
  year={2000},
  volume={12}
}
Limbic status epilepticus was induced in rats by unilateral 60‐min electrical stimulation of the CA3 region of the ventral hippocampus. As assessed by RT‐PCR followed by Southern blot analysis, transcripts of interleukin‐1β, interleukin‐6, interleukin‐1 receptor antagonist and inducible nitric oxide synthase were significantly increased 2 h after status epilepticus in the stimulated hippocampus. Induction was maximal at 6 h for interleukin‐1β (445%), interleukin‐6 (405%) and tumour necrosis… Expand
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Investigation of the effect of lovastatin on body temperature and on mRNA expression levels of hippocampal cytokines of rats submitted to pilocarpine-induced status epilepticus found it reduced SE-induced hyperthermia, indicating mechanisms related to brain protection are triggered by this drug under conditions associated with acute excitotoxicity or long-lasting SE. Expand
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