Inflammatory cytokines and cell death in BEAS-2B lung cells treated with soil dust, lipopolysaccharide, and surface-modified particles.

@article{Veranth2004InflammatoryCA,
  title={Inflammatory cytokines and cell death in BEAS-2B lung cells treated with soil dust, lipopolysaccharide, and surface-modified particles.},
  author={John M. Veranth and Christopher A. Reilly and Martha M Veranth and Tyler A. Moss and Charles R Langelier and Diane L. Lanza and Garold S. Yost},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2004},
  volume={82 1},
  pages={88-96}
}
Cultured human lung epithelial cells (BEAS-2B) were treated in vitro with PM(2.5)-enriched particles of soil-derived mineral dust from nine sites in the western United States. The particle samples simulate windblown dust and vehicle-generated emissions from unpaved roads. Five of the sites yielded relatively benign dust. Particles from three sites caused IL-6 release when cells were treated for 24 h at doses from 20 to 80 microg/cm(2), and particles from one site were highly cytotoxic. The… CONTINUE READING

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