Inflammatory cytokines, angiogenesis, and fibrosis in the rat peritoneum.

  title={Inflammatory cytokines, angiogenesis, and fibrosis in the rat peritoneum.},
  author={Peter J Margetts and Martin Kolb and Lisa Yu and C. Michael Hoff and Clifford John Holmes and Daniel C. Anthony and Jack Gauldie},
  journal={The American journal of pathology},
  volume={160 6},
Peritonitis, a common complication of peritoneal dialysis, is followed by acute changes in the function of the peritoneum. The role of inflammatory cytokines in these processes is not clearly identified. We used adenoviral-mediated gene transfer to transiently overexpress interleukin (IL)-1 beta (AdIL-1 beta) or tumor necrosis factor (TNF)-alpha (AdTNF-alpha) in the rat peritoneum then used a modified equilibrium test to study the histological and functional changes. Overexpression of IL-1 beta… CONTINUE READING


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