Inflammatory cytokine release of astrocytes in vitro is reduced by all-trans retinoic acid.

Abstract

In the central nervous system inflammation is mediated by microglia and astrocytes. To investigate its regulation, murine astrocyte cultures were treated with bacterial lipopolysaccharides (LPS) and analyzed with Affymetrix gene array, qRT-PCR and ELISA. Cells responded to LPS with a strong upregulation of pro-inflammatory cytokines and chemokines… (More)
DOI: 10.1016/j.jneuroim.2010.08.005