Inflammatory bowel disease epidemiology

  title={Inflammatory bowel disease epidemiology},
  author={Johan Burisch and Pia Munkholm},
  journal={Current Opinion in Gastroenterology},
Purpose of review The occurrence of inflammatory bowel disease (IBD) is increasing worldwide, yet the reasons remain unknown. New therapeutic approaches have been introduced in medical IBD therapy, but their impact on the natural history of IBD remains uncertain. This review will summarize the recent findings in the epidemiology of IBD. Recent findings The incidence of IBD in western Europe is twice as high as in eastern Europe, whereas the highest IBD incidence in the world is found in the… 
Epidemiology and Natural History of IBD in the Paediatric Age
The inflammatory bowel diseases (IBD) are chronic inflammatory conditions of the gastrointestinal tract characterised by episodes of relapse and remission, and its emergence as a global disease suggests that environmental factors are likely playing a major role in modifying disease expression.
Crohn's disease and ulcerative colitis. Occurrence, course and prognosis during the first year of disease in a European population-based inception cohort.
A prospective European population-based inception cohort of incident IBD patients was created to investigate whether an East-West gradient in the incidence of IBD exists in Europe and whether the earlier and more frequent treatment with immunomodulators and biologicals observed in this study will change the natural disease course and phenotypes over time.
Biological therapy and surgery rates in inflammatory bowel diseases – Data analysis of almost 1000 patients from a Hungarian tertiary IBD center
This analysis revealed that more than 1 year of diagnostic delay, disease activity at diagnosis in UC, CD, ileal location and penetrating behaviour are factors that may influence disease outcome.
The risk of colorectal cancer is related to frequent hospitalization of IBD in an Asian population: results from a nationwide study.
The risk for CRC was not increased among IBD patients overall, but appeared to be increased with cumulative frequency of hospitalizations for IBD, as well as in low endemic areas, such as Asia.
Inflammatory bowel disease imaging: Current practice and future directions.
The paper discusses, in detail the pros and cons of the different IBD imaging modalities that need to be considered in order to optimize the imaging and clinical evaluation of patients with IBD.
Correlation of Biomarker Expression in Colonic Mucosa with Disease Phenotype in Crohn’s Disease and Ulcerative Colitis
This approach could be used as a model for molecular classification of IBD patients, which could be enhanced by the inclusion of additional genes that are identified by functional studies, global gene expression analyses, and genome-wide association studies.
Colitis-associated colon cancer: Is it in your genes?
The current CA-CRC literature is summarized with a strong focus on genetic pre-disposition and an emerging role for mouse models in the search for CA- CRC risk alleles is highlighted.
Efficacy of vitamin D in treatment of inflammatory bowel disease
The treatment of VitD in patients with IBD can improve the level of 25(OH)D3 and control the relapse rate of the disease, whose clinical curative effect is more accurate.
MR Enterography of Inflammatory Bowel Disease with Endoscopic Correlation.
Understanding the endoscopic features of IBD and the pathologic processes that cause the MR enterographic findings can help improve the accuracy of disease characterization and thus optimize the medication and surgical therapies for these patients.
Pursuing therapeutic success in Crohn’s disease: A matter of definition, tools and longterm outcomes
Therapeutic drug monitoring is essential in assessing loss of response and making therapeutic decisions, although firm recommendations are not implemented into daily practice, and extraintestinal manifestations are often disregarded when discussing monitoring protocols.


Inflammatory bowel disease in Asia: A systematic review
In Asia, UC is more prevalent than CD, although CD incidence is rapidly increasing in certain areas, and there is a male predominance of CD in Asia, but a trend towards equal sex distribution for UC.
Rapid rise in incidence of Irish paediatric inflammatory bowel disease
There has been a substantial and sustained increase in the incidence of childhood UC and CD in Ireland over a relatively short period of time, however, disease phenotype at diagnosis has not changed and CD appears to progress less frequently than in some neighbouring countries.
Trends in overall and cause-specific mortality among patients with inflammatory bowel disease from 1982 to 2010.
  • T. Jess, M. Frisch, J. Simonsen
  • Medicine
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • 2013
Rising incidence of pediatric inflammatory bowel disease in Scotland*
The number of Scottish children diagnosed with IBD continues to rise, with a statistically significant 76% increase since the mid‐1990s, and PIBD is now being diagnosed at a younger age.
Incidence, disease phenotype at diagnosis, and early disease course in inflammatory bowel diseases in Western Hungary, 2002–2006
The incidence of IBD in Veszprem Province in the last decade was high, equal to that in high‐incidence areas in Western European countries.
Clostridium difficile infection: epidemiology, risk factors and management
The first-line agents for CDI treatment are metronidazole and vancomycin, with the latter being the preferred agent in patients with severe disease as it has significantly superior efficacy.
Increasing Incidence of Pediatric Inflammatory Bowel Disease in Spain (1996–2009): The SPIRIT Registry
In the last 14 years pediatric IBD incidence has almost tripled, with a more important CD increase, and a significant increase of incidence rates in the study period was observed.
Crohn’s Disease and Ulcerative Colitis Are Associated With Elevated Standardized Mortality Ratios: A Meta-Analysis
Patients with UC and CD have higher rates of death from all causes, colorectal-cancer, pulmonary disease, and nonalcoholic liver disease, whereas mortality from cardiovascular disease was decreased.