Inflammatory bowel disease: no association between allele combinations of the interleukin (IL) I beta and IL-I receptor antagonist gene polymorphisms.

@article{Hacker1998InflammatoryBD,
  title={Inflammatory bowel disease: no association between allele combinations of the interleukin (IL) I beta and IL-I receptor antagonist gene polymorphisms.},
  author={Ulrich T. Hacker and Christoph Bidlingmaier and Maria Gomolka and Eberhard Keller and Andreas Eigler and Gunther Hartmann and Christian Folwaczny and Harald Fricke and Ekkehard Albert and Klaus Loeschke and Stefan C. Endres},
  journal={European journal of clinical investigation},
  year={1998},
  volume={28 3},
  pages={214-9}
}
BACKGROUND Interleukin 1 (IL-1) and its physiological antagonist interleukin-1 receptor antagonist (IL-1 ra) play a crucial role in the pathogenesis of inflammatory bowel disease. Polymorphisms in the genes coding for these cytokines, the restriction enzyme TaqI polymorphism for IL-1 beta and the variable number of tandem repeats (VNTR) polymorphism for IL-1 ra, have been shown to influence cytokine synthesis in vitro. Recently, an association has been described for distinct allele combinations… CONTINUE READING

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