Inflammatory bowel disease: mechanisms, redox considerations, and therapeutic targets.

@article{Biasi2013InflammatoryBD,
  title={Inflammatory bowel disease: mechanisms, redox considerations, and therapeutic targets.},
  author={Fiorella Biasi and Gabriella Leonarduzzi and Patricia I Oteiza and Giuseppe Poli},
  journal={Antioxidants & redox signaling},
  year={2013},
  volume={19 14},
  pages={1711-47}
}
Oxidative stress is thought to play a key role in the development of intestinal damage in inflammatory bowel disease (IBD), because of its primary involvement in intestinal cells' aberrant immune and inflammatory responses to dietary antigens and to the commensal bacteria. During the active disease phase, activated leukocytes generate not only a wide spectrum of pro-inflammatory cytokines, but also excess oxidative reactions, which markedly alter the redox equilibrium within the gut mucosa, and… CONTINUE READING

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References

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Showing 1-10 of 299 references

Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis.

Proceedings of the National Academy of Sciences of the United States of America • 2005
View 7 Excerpts
Highly Influenced

The resolution of inflammation: the devil in the flask and in the details.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2011
View 4 Excerpts
Highly Influenced

Intestinal Goblet Cells and Mucins in Health and Disease: Recent Insights and Progress

Current gastroenterology reports • 2010
View 3 Excerpts
Highly Influenced

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