Inflammatory bowel disease: mechanisms, redox considerations, and therapeutic targets.

  title={Inflammatory bowel disease: mechanisms, redox considerations, and therapeutic targets.},
  author={Fiorella Biasi and Gabriella Leonarduzzi and Patricia I Oteiza and Giuseppe Poli},
  journal={Antioxidants & redox signaling},
  volume={19 14},
Oxidative stress is thought to play a key role in the development of intestinal damage in inflammatory bowel disease (IBD), because of its primary involvement in intestinal cells' aberrant immune and inflammatory responses to dietary antigens and to the commensal bacteria. During the active disease phase, activated leukocytes generate not only a wide spectrum of pro-inflammatory cytokines, but also excess oxidative reactions, which markedly alter the redox equilibrium within the gut mucosa, and… CONTINUE READING


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