Inflammatory bowel disease: cause and immunobiology

@article{Baumgart2007InflammatoryBD,
  title={Inflammatory bowel disease: cause and immunobiology},
  author={Daniel C. Baumgart and Simon R. Carding},
  journal={The Lancet},
  year={2007},
  volume={369},
  pages={1627-1640}
}
Crohn's disease and ulcerative colitis are idiopathic inflammatory bowel disorders. In this paper, we discuss how environmental factors (eg, geography, cigarette smoking, sanitation and hygiene), infectious microbes, ethnic origin, genetic susceptibility, and a dysregulated immune system can result in mucosal inflammation. After describing the symbiotic interaction of the commensal microbiota with the host, oral tolerance, epithelial barrier function, antigen recognition, and immunoregulation… Expand

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