Inflammatory and anti-glioma effects of an adenovirus expressing human soluble Fms-like tyrosine kinase 3 ligand (hsFlt3L): treatment with hsFlt3L inhibits intracranial glioma progression.

@article{Ali2004InflammatoryAA,
  title={Inflammatory and anti-glioma effects of an adenovirus expressing human soluble Fms-like tyrosine kinase 3 ligand (hsFlt3L): treatment with hsFlt3L inhibits intracranial glioma progression.},
  author={Sumia Ali and James F Curtin and Jeffrey M Zirger and Weidong Xiong and Gwendalyn D. King and Carlos Barcia and Chun-yan Liu and Mariana Puntel and Shyam Goverdhana and Pedro Ricardo Lowenstein and Maria Graciela Castro},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2004},
  volume={10 6},
  pages={1071-84}
}
Glioblastoma multiforme is an intracranial tumor that has very poor prognosis. Patients usually succumb to their disease 6 to 12 months after they are diagnosed despite very aggressive treatment modalities. We tested the efficacy of a potent differentiation and proliferation factor for the professional antigen-presenting dendritic cells (DCs), i.e., Flt3L, for its potential role as a novel therapy for gliomas. We investigated the ability of recombinant adenoviral vectors encoding human soluble… CONTINUE READING

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