Inflammatory alterations in mesenteric adipose tissue in Crohn's disease.

  title={Inflammatory alterations in mesenteric adipose tissue in Crohn's disease.},
  author={Pierre Desreumaux and Olivier Ernst and Karel Geboes and Luc Gambiez and Dominique Berrebi and Heide M{\"u}ller-Alouf and Samira Hafraoui and Dominique Emilie and Nadine L E Y Ectors and Michel Peuchmaur and Antoine Cortot and Monique Capron and Johan Auwerx and Jean Francois Colombel},
  volume={117 1},
BACKGROUND & AIMS Abnormalities of fat in the mesentery including adipose tissue hypertrophy and fat wrapping have been long recognized on surgical specimens as characteristic features of Crohn's disease. However, the importance, origin, and significance of the mesenteric fat hypertrophy in this chronic inflammatory disease are unknown. Peroxisome proliferator-activated receptor gamma (PPARgamma) is a crucial factor involved in the homeostasis of adipose tissue, a major source of biologically… CONTINUE READING
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