Inflammatory agonists induce cyclooxygenase type 2 expression by human neutrophils.

@article{Maloney1998InflammatoryAI,
  title={Inflammatory agonists induce cyclooxygenase type 2 expression by human neutrophils.},
  author={Christopher G. Maloney and William A. Kutchera and Kurt H. Albertine and Thomas M McIntyre and Stephen M. Prescott and Guy A Zimmerman},
  journal={Journal of immunology},
  year={1998},
  volume={160 3},
  pages={
          1402-10
        }
}
The synthesis of prostanoids is regulated by cyclooxygenases (prostaglandin H synthases), which catalyze the conversion of arachidonic acid to PGH2. Cyclooxygenases are the target of aspirin and other nonsteroidal anti-inflammatory agents. In this study, we found that human polymorphonuclear leukocytes (PMNs) express the inducible isoform of cyclooxygenase, COX-2, when stimulated by LPS whereas the protein was not detectable in freshly isolated human PMNs. We also found by immunohistochemical… CONTINUE READING

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