Inflammatory Properties and Adjuvant Potential of Synthetic Glycolipids Homologous to Mycolate Esters of the Cell Wall of Mycobacterium tuberculosis.

@article{Tima2017InflammatoryPA,
  title={Inflammatory Properties and Adjuvant Potential of Synthetic Glycolipids Homologous to Mycolate Esters of the Cell Wall of Mycobacterium tuberculosis.},
  author={Hermann Giresse Tima and Juma''a Raheem Al Dulayymi and Olivier Denis and Pauline Lehebel and Klarah Sherzad Baols and Mohsin Omar Mohammed and Laurent L'homme and Mohaned Mohammed Sahb and Georges Potemberg and Sylvie Legrand and Roland Lang and Rudi Beyaert and Jacques Piette and Mark S Baird and Kris Huygen and Marta Romano},
  journal={Journal of innate immunity},
  year={2017},
  volume={9 2},
  pages={
          162-180
        }
}
The cell wall of mycobacteria is characterised by glycolipids composed of different classes of mycolic acids (MAs; alpha-, keto-, and methoxy-) and sugars (trehalose, glucose, and arabinose). Studies using mutant Mtb strains have shown that the structure of MAs influences the inflammatory potential of these glycolipids. As mutant Mtb strains possess a complex mixture of glycolipids, we analysed the inflammatory potential of single classes of mycolate esters of the Mtb cell wall using 38… CONTINUE READING
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Arabinose mycolates from synthetic mycolic acids

  • M. Mohammed
  • PhD thesis, Bangor Univ
  • 2015

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