Inflammatory Neurodegeneration and Mechanisms of Microglial Killing of Neurons

  title={Inflammatory Neurodegeneration and Mechanisms of Microglial Killing of Neurons},
  author={Guy C Brown and Jonas J Neher},
  journal={Molecular Neurobiology},
Inflammatory neurodegeneration contributes to a wide variety of brain pathologies. A number of mechanisms by which inflammatory-activated microglia and astrocytes kill neurons have been identified in culture. These include: (1) acute activation of the phagocyte NADPH oxidase (PHOX) found in microglia, (2) expression of the inducible nitric oxide synthase (iNOS) in glia, and (3) microglial phagocytosis of neurons. Activation of PHOX (by cytokines, β-amyloid, prion protein, lipopolysaccharide… CONTINUE READING
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